Molecular weight (DA)
75kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
THOP1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a kininase that uses zinc as a cofactor. The encoded oligopeptidase cleaves cytosolic peptides, making them unavailable for display on antigen-presenting cells. This protein also cleaves neuropeptides under 20 aa in length and can degrade beta-amyloid precursor protein to amyloidogenic peptides. [provided by RefSeq, Nov 2015],
Function
catalytic activity:Preferential cleavage of bonds with hydrophobic residues at P1, P2 and P3' and a small residue at P1' in substrates of 5 to 15 residues.,cofactor:Binds 1 zinc ion per subunit.,cofactor:Binds 1 zinc ion.,function:Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation. Able to degrade the beta-amyloid precursor protein and generate amyloidogenic fragments.,similarity:Belongs to the peptidase M3 family.,subunit:Monomer.,
Protein name
Thimet oligopeptidase (EC 3.4.24.15) (Endopeptidase 24.15) (MP78)
Fields
>>Renin-angiotensin system;>>African trypanosomiasis
Human protein sequence Database
P52888
Mouse protein sequence database
Q8C1A5
Rat protein sequence database
P24155
Cellular localization
Cytoplasm.
Tissue expression
Brain,Lung,Placenta,Uterus,
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