Molecular weight (DA)
50kD
Immunogen
Synthesized peptide derived from eIF2Bγ . at AA range: 240-320
Specificity
eIF2Bγ Polyclonal Antibody detects endogenous levels of eIF2Bγ protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is one of the subunits of initiation factor eIF2B, which catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. It has also been found to function as a cofactor of hepatitis C virus internal ribosome entry site-mediated translation. Mutations in this gene have been associated with leukodystrophy with vanishing white matter. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009],
Function
alternative products:Experimental confirmation may be lacking for some isoforms,disease:Defects in EIF2B3 are a cause of leukodystrophy with vanishing white matter (VWM) [MIM:603896]. VWM is a leukodystrophy that occurs mainly in children. Neurological signs include progressive cerebellar ataxia, spasticity, inconstant optic atrophy and relatively preserved mental abilities. The disease is chronic-progressive with, in most individuals, additional episodes of rapid deterioration following febrile infections or minor head trauma. While childhood onset is the most common form of the disorder, some severe forms are apparent at birth. A severe, early-onset form seen among the Cree and Chippewayan populations of Quebec and Manitoba is called Cree leukoencephalopathy. Milder forms may not become evident until adolescence or adulthood. Some females with milder forms of the disease who survive to
Protein name
Translation initiation factor eIF-2B subunit gamma
Other name
EIF2B3; Translation initiation factor eIF-2B subunit gamma; eIF-2B GDP-GTP exchange factor subunit gamma
Fields
>>Herpes simplex virus 1 infection
Human protein sequence Database
Q9NR50
Mouse protein sequence database
Rat protein sequence database
Cellular localization
cytoplasm,cytosol,eukaryotic translation initiation factor 2B complex,
Tissue expression
Blood,Hepatoma,Lymph node,Mammary gland,
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