Molecular weight (DA)
76kD
Immunogen
Synthesized peptide derived from part region of human protein. AA range 655-675
Specificity
UVRAG Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer. [provided by RefSeq, Jul 2008],
Function
disease:Disrupted by a Inv(11)(q13.5;q25) inversion in a patient with heterotaxy (left-right axis malformation).,similarity:Contains 1 C2 domain.,tissue specificity:Highly expressed in brain, lung, kidney and liver.,
Protein name
UV radiation resistance-associated gene protein (p63)
Fields
>>Autophagy - animal
Human protein sequence Database
Q9P2Y5
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Late endosome . Lysosome . Cytoplasmic vesicle, autophagosome . Early endosome . Endoplasmic reticulum . Midbody . Chromosome, centromere . Colocalizes with RAB9-positive compartments involved in retrograde transport from late endosomes to trans-Golgi network. Colocalization with early endosomes is only partial (PubMed:24056303). Recruited to autophagosome following interaction with RUBCNL/PACER (PubMed:28306502). .
Tissue expression
Highly expressed in brain, lung, kidney and liver.
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