Molecular weight (DA)
21kD
Immunogen
Synthesized peptide derived from part region of human protein AA range: 101-150
Specificity
TNF18 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells. [provided by RefSeq, Jul 2008],
Function
function:Cytokine that binds to TNFRSF18/AITR/GITR. Important for interactions between activated T-lymphocytes and endothelial cells and may modulate T-lymphocyte survival in peripheral tissues.,induction:Up-regulated after stimulation by lipopolysaccharides.,similarity:Belongs to the tumor necrosis factor family.,subunit:Homotrimer .,tissue specificity:Expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells.,
Gene Name
TNFSF18 AITRL GITRL TL6 UNQ149/PRO175
Protein name
Tumor necrosis factor ligand superfamily member 18 (Activation-inducible TNF-related ligand) (AITRL) (Glucocorticoid-induced TNF-related ligand) (hGITRL)
Fields
>>Cytokine-cytokine receptor interaction
Human protein sequence Database
Q9UNG2
Mouse protein sequence database
Q7TS55
Rat protein sequence database
Cellular localization
Cell membrane ; Single-pass type II membrane protein .
Tissue expression
Expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells.
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