Molecular weight (DA)
92kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 310-390
Specificity
LZTR1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the BTB-kelch superfamily. Initially described as a putative transcriptional regulator based on weak homology to members of the basic leucine zipper-like family, the encoded protein subsequently has been shown to localize exclusively to the Golgi network where it may help stabilize the Gogli complex. Deletion of this gene may be associated with DiGeorge syndrome. [provided by RefSeq, Jul 2008],
Function
developmental stage:Expressed in fetal brain, heart, kidney, liver and lung.,disease:May play a part in the etiology of the velocardiofacial/DiGeorge syndrome (VCFS/DGS), a developmental disorder characterized by structural and functional palate anomalies, conotruncal cardiac malformations, immunodeficiency, hypocalcemia, and typical facial anomalies. Most cases result from a deletion of chromosome 22q11.2 (the DiGeorge syndrome chromosome region, or DGCR).,function:Probable transcriptional regulator that may play a crucial role in embryogenesis.,similarity:Contains 2 BTB (POZ) domains.,similarity:Contains 6 Kelch repeats.,
Protein name
Leucine-zipper-like transcriptional regulator 1 (LZTR-1)
Human protein sequence Database
Q8N653
Mouse protein sequence database
Q9CQ33
Rat protein sequence database
Cellular localization
Endomembrane system . Recycling endosome . Golgi apparatus .
Tissue expression
Brain,Duodenal adenocarcinoma,Fetal brain,
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