Molecular weight (DA)
47kD
Immunogen
The antiserum was produced against synthesized peptide derived from human Carboxypeptidase A1. AA range:301-350
Specificity
CPA1 Polyclonal Antibody detects endogenous levels of CPA1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the carboxypeptidase A family of zinc metalloproteases. This enzyme is produced in the pancreas and preferentially cleaves C-terminal branched-chain and aromatic amino acids from dietary proteins. This gene and several family members are present in a gene cluster on chromosome 7. Mutations in this gene may be linked to chronic pancreatitis, while elevated protein levels may be associated with pancreatic cancer. [provided by RefSeq, Jan 2015],
Function
catalytic activity:Release of a C-terminal amino acid, but little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.,cofactor:Binds 1 zinc ion per subunit.,similarity:Belongs to the peptidase M14 family.,subunit:Monomer. May form a complex with proelastase 2.,
Protein name
Carboxypeptidase A1
Other name
CPA1; CPA; Carboxypeptidase A1
Fields
>>Pancreatic secretion;>>Protein digestion and absorption
Human protein sequence Database
P15085
Mouse protein sequence database
Q7TPZ8
Rat protein sequence database
Cellular localization
Secreted.
Tissue expression
Pancreas,
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