Molecular weight (DA)
89kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
SL9A2 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the sodium-hydrogen exchanger (NHE) protein family. These proteins are involved in sodium-ion transport by exchanging intracellular hydrogen ions to external sodium ions and help in the regulation of cell pH and volume. The encoded protein is localized to the apical membrane and is involved in apical absorption of sodium. [provided by RefSeq, Jun 2016],
Function
caution:The number, localization and denomination of hydrophobic domains in the Na(+)/H(+) exchangers vary among authors.,function:Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Seems to play an important role in colonic sodium absorption.,PTM:Phosphorylated (Possible).,similarity:Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.,tissue specificity:Expressed in skeletal muscle, colon and kidney. Lower levels in the testis, prostate, ovary, and small intestine.,
Protein name
Sodium/hydrogen exchanger 2 (Na(+)/H(+) exchanger 2) (NHE-2) (Solute carrier family 9 member 2)
Human protein sequence Database
Q9UBY0
Mouse protein sequence database
Rat protein sequence database
P48763
Cellular localization
Membrane; Multi-pass membrane protein.
Tissue expression
Expressed in skeletal muscle, colon and kidney. Lower levels in the testis, prostate, ovary, and small intestine.
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