Molecular weight (DA)
43kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
SEC62 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC63 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. [provided by RefSeq, Jul 2008],
Function
function:Required for preprotein translocation.,similarity:Belongs to the SEC62 family.,subunit:Part of a complex that contains SEC61, SEC62 and SEC63. Interacts with SEC61B.,
Protein name
Translocation protein SEC62 (Translocation protein 1) (TP-1) (hTP-1)
Fields
>>Protein export;>>Protein processing in endoplasmic reticulum
Human protein sequence Database
Q99442
Mouse protein sequence database
Q8BU14
Rat protein sequence database
Cellular localization
Endoplasmic reticulum membrane ; Multi-pass membrane protein .
Tissue expression
Epithelium,Liver,Mammary gland,Prostate,
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