Molecular weight (DA)
92kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 560-640
Specificity
ARHGF Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein-coupled receptors. This gene encodes a protein that functions as a specific guanine nucleotide exchange factor for RhoA. It also interacts with ephrin A4 in vascular smooth muscle cells. Two alternatively spliced transcripts variants that encode the same protein have been found for this gene. [provided by RefSeq, Aug 2010],
Function
function:Specific GEF for RhoA activation and the regulation of vascular smooth muscle contractility.,PTM:Phosphorylated on tyrosine residues upon EFNA1 stimulation.,similarity:Contains 1 DH (DBL-homology) domain.,subunit:Interacts with EPHA4.,tissue specificity:Expressed in the vascular smooth muscle of coronary artery.,
Gene Name
ARHGEF15 KIAA0915
Protein name
Rho guanine nucleotide exchange factor 15 (Ephexin-5) (E5) (Vsm-RhoGEF)
Human protein sequence Database
O94989
Mouse protein sequence database
Q5FWH6
Rat protein sequence database
Cellular localization
Cell projection, dendrite . Expressed exclusively in dendrites of the developing hippocampus. .
Tissue expression
Expressed in the vascular smooth muscle of coronary artery.
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