DDX8 Polyclonal Antibody

Polyclonal antibody

Specification

BYab-01648

50UL $180 100UL $255
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Product introduction Experimental scheme Citation Related products

Product introduction>

Host

Reactiveness

Use

Molecular weight (DA)

150kD

Immunogen

The antiserum was produced against synthesized peptide derived from human DHX8. AA range:391-440

Specificity

DDX8 Polyclonal Antibody detects endogenous levels of DDX8 protein.

Source

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Dilution rate

Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.

Purification process (Immunogen)

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Background

This gene is a member of the DEAH box polypeptide family. The encoded protein contains the DEAH (Asp-Glu-Ala-His) motif which is characteristic of all DEAH box proteins, and is thought to function as an ATP-dependent RNA helicase that regulates the release of spliced mRNAs from spliceosomes prior to their export from the nucleus. This protein may be required for the replication of human immunodeficiency virus type 1 (HIV-1). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014],

Function

domain:The RS domain confers a nuclear localization signal, and appears to facilitate the interaction with the spliceosome.,function:Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome.,similarity:Belongs to the DEAD box helicase family. DEAH subfamily. DDX8/PRP22 sub-subfamily.,similarity:Contains 1 helicase ATP-binding domain.,similarity:Contains 1 helicase C-terminal domain.,similarity:Contains 1 S1 motif domain.,subunit:Identified in the spliceosome C complex, at least composed of AQR, C19orf29, CDC40, CDC5L, CRNKL1, DDX23, DDX41, DDX48, DDX5, DGCR14, DHX35, DHX38, DHX8, EFTUD2, FRG1, GPATC1, HNRPA1, HNRPA2B1, HNRPA3, HNRPC, HNRPF, HNRPH1, HNRPK, HNRPM, HNRPR, HNRPU, KIAA1160, KIAA1604, LSM2, LSM3, MAGOH, MORG1, PABPC1, PLRG1, PNN, PPIE, PPIL1, PPIL3, PPWD1, PRPF19, PRPF4B, PRPF6, PRPF8, RALY, RBM22, RBM8A, RBMX, SART1, SF3A1, SF3A2, SF3A3, SF3B1, SF3

Gene Name

DHX8

Protein name

ATP-dependent RNA helicase DHX8

Abbreviation

DDX8

Other name

DHX8; DDX8; ATP-dependent RNA helicase DHX8; DEAH box protein 8; RNA helicase HRH1

Fields

>>Spliceosome

Human gene ID

1659

Human protein sequence Database

Q14562

Mouse gene ID

217207

Mouse protein sequence database

A2A4P0

Rat gene ID

Rat protein sequence database

Cellular localization

Nucleus .

Tissue expression

Expressed in skin, cervix and nerve. Also expressed in the brain.

Storage

-20°C/1 year

Experimental scheme>

Procedure

DDX8 Polyclonal Antibody

BYab-01648

Product introduction>

Host

Reactiveness

Use

Molecular weight (DA)

Immunogen

Specificity

Source

Formulation

Dilution rate

Purification process (Immunogen)

Concentration

Background

Function

Gene Name

Protein name

Abbreviation

Other name

Fields

Human gene ID

Human protein sequence Database

Mouse gene ID

Mouse protein sequence database

Rat gene ID

Rat protein sequence database

Cellular localization

Tissue expression

Storage

Experimental scheme>

Citation>

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DDX8 Polyclonal Antibody

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