Molecular weight (DA)
30kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 90-170
Specificity
RB40L Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the Rab40 subfamily of Rab small GTP-binding proteins that contains a C-terminal suppressors of cytokine signaling box. Disruptions in this gene are associated with Duchenne muscular dystrophy. [provided by RefSeq, Apr 2010],
Function
domain:The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.,function:May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.,pathway:Protein modification; protein ubiquitination.,similarity:Belongs to the small GTPase superfamily. Rab family.,similarity:Contains 1 SOCS box domain.,tissue specificity:Expressed in brain, heart, skeletal muscle, kidney and liver. Highest expression in brain.,
Protein name
Ras-related protein Rab-40A-like (Ras-like GTPase)
Human protein sequence Database
P0C0E4
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Membrane ; Lipid-anchor ; Cytoplasmic side . Cytoplasm . Mitochondrion .
Tissue expression
Expressed in brain, lung, heart, skeletal muscle, kidney and liver. Highest expression in brain. Expressed in fetal brain and kidney.
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