Molecular weight (DA)
33kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 230-310
Specificity
KCNKG Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
potassium two pore domain channel subfamily K member 16(KCNK16) Homo sapiens The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations. This gene is expressed predominantly in the pancreas and is activated at alkaline pH. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Sep 2008],
Function
function:Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents.,miscellaneous:Inhibited by Ba(2+), quinine, quinidine, chloroform and halothane. Activated at alkaline pH.,similarity:Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.,subunit:Homodimer .,tissue specificity:Highly expressed in pancreas. Not detectable in the other tissues tested.,
Protein name
Potassium channel subfamily K member 16 (2P domain potassium channel Talk-1) (TWIK-related alkaline pH-activated K(+) channel 1) (TALK-1)
Human protein sequence Database
Q96T55
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Membrane; Multi-pass membrane protein.
Tissue expression
Highly expressed in pancreas. Not detectable in the other tissues tested.
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