Molecular weight (DA)
54kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 80-160
Specificity
ACHA6 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes an alpha subunit of neuronal nicotinic acetylcholine receptors. These receptors consist of five subunits and function as ion channels involved in neurotransmission. The encoded protein is a subunit of neuronal nicotinic acetylcholine receptors that mediate dopaminergic neurotransmission and are activated by acetylcholine and exogenous nicotine. Alternatively spliced transcript variants have been observed for this gene. Single nucleotide polymorphisms in this gene have been associated with both nicotine and alcohol dependence. [provided by RefSeq, Dec 2010],
Function
function:After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.,similarity:Belongs to the ligand-gated ionic channel (TC 1.A.9) family.,subunit:Neuronal AChR seems to be composed of two different types of subunits: alpha and non-alpha (beta).,
Protein name
Neuronal acetylcholine receptor subunit alpha-6
Fields
>>Neuroactive ligand-receptor interaction;>>Cholinergic synapse;>>Nicotine addiction
Human protein sequence Database
Q15825
Mouse protein sequence database
Q9R0W9
Rat protein sequence database
P43143
Cellular localization
Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Tissue expression
Epithelium,Skin,Substantia nigra,
Contract Us
Follow Us
Location： 
Specification
成功添加到购物车