Molecular weight (DA)
42kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 260-340
Specificity
MADCA Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin family and is similar to ICAM1 and VCAM1. At least seven alternatively spliced transcripts encoding different protein isoforms have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008],
Function
alternative products:Additional isoforms seem to exist,function:Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding.,polymorphism:The number of repeats in the mucin domain varies between 5 and 8 repeats.,PTM:The Ser/Thr-rich mucin-like domain may provide possible sites for O-glycosylation.,similarity:Contains 2 Ig-like (immunoglobulin-like) domains.,subunit:Homodimer.,tissue specificity:Highly expressed on high endothelial venules (HEV) and lamina propia venules found in the small int
Protein name
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1) (hMAdCAM-1)
Fields
>>Cell adhesion molecules;>>Intestinal immune network for IgA production
Human protein sequence Database
Q13477
Mouse protein sequence database
Q61826
Rat protein sequence database
O70540
Cellular localization
Membrane; Single-pass type I membrane protein.
Tissue expression
Highly expressed on high endothelial venules (HEV) and lamina propia venules found in the small intestine, and to a lesser extent in the colon and spleen. Very low levels of expression found in pancreas and brain. Not expressed in the thymus, prostate, ovaries, testis, heart, placenta, lung, liver, skeletal muscle, kidney or peripheral blood leukocytes.
Contract Us
Follow Us
Location： 
Specification
成功添加到购物车