Molecular weight (DA)
44kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 260-340
Specificity
MNX1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a nuclear protein, which contains a homeobox domain and is a transcription factor. Mutations in this gene result in Currarino syndrome, an autosomic dominant congenital malformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009],
Function
disease:Defects in MNX1 are a cause of Currarino syndrome [MIM:176450]. The triad of a presacral tumor, sacral agenesis and anorectal malformation constitutes the Currarino syndrome which is caused by dorsal-ventral patterning defects during embryonic development. The syndrome occurs in the majority of patients as an autosomal dominant trait.,function:Putative transcription factor involved in pancreas development and function.,similarity:Contains 1 homeobox DNA-binding domain.,tissue specificity:Expressed in lymphoid and pancreatic tissues.,
Protein name
Motor neuron and pancreas homeobox protein 1 (Homeobox protein HB9)
Fields
>>Maturity onset diabetes of the young
Human protein sequence Database
P50219
Mouse protein sequence database
Q9QZW9
Rat protein sequence database
Cellular localization
Nucleus.
Tissue expression
Expressed in lymphoid and pancreatic tissues.
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