Molecular weight (DA)
60kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
GNL3 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene may interact with p53 and may be involved in tumorigenesis. The encoded protein also appears to be important for stem cell proliferation. This protein is found in both the nucleus and nucleolus. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010],
Function
domain:In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern.,domain:The basic domain (B) allows nucleolar localization in the absence of GTP. The intermediate domain (I) inhibits nucleolar localization by the B domain and is required for exit from the nucleolus. Exit from the nucleolus to the nucleoplasm requires both the I and the acidic (A) domains, and may be triggered by GTP hydrolysis.,function:May be required to maintain the proliferative capacity of stem cells and may play an important role in tumorigenesis.,similarity:Belongs to the MMR1/HSR1 GTP-binding protein family.,subcellular location:Shuttles between the nucleus and nucleolus.,subunit:May interact with p53/TP53 via its basic domain.,tissue specificity:Increased levels in lung tissue in cancer patients.,
Protein name
Guanine nucleotide-binding protein-like 3 (E2-induced gene 3 protein) (Novel nucleolar protein 47) (NNP47) (Nucleolar GTP-binding protein 3) (Nucleostemin)
Fields
>>Ribosome biogenesis in eukaryotes
Human protein sequence Database
Q9BVP2
Mouse protein sequence database
Q8CI11
Rat protein sequence database
Q811S9
Cellular localization
Nucleus . Nucleus, nucleolus . Shuttles between the nucleus and nucleolus. .
Tissue expression
Increased levels in lung tissue in cancer patients.
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