Molecular weight (DA)
75kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 550-630
Specificity
NKRF Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a transcriptional repressor that interacts with specific negative regulatory elements to mediate transcriptional repression of certain nuclear factor kappa B responsive genes. The protein localizes predominantly to the nucleolus with a small fraction found in the nucleoplasm and cytoplasm. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010],
Function
function:Interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes. Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity. Also involved in the regulation of IL-8 transcription.,similarity:Contains 1 G-patch domain.,similarity:Contains 1 R3H domain.,subunit:Interacts with NF-kappa-B.,tissue specificity:Widely and constitutively expressed. Expressed at lower level in colon, peripheral blood lymphocytes, lung and kidney.,
Protein name
NF-kappa-B-repressing factor (NFkB-repressing factor) (Protein ITBA4) (Transcription factor NRF)
Human protein sequence Database
O15226
Mouse protein sequence database
Q8BY02
Rat protein sequence database
Cellular localization
Nucleus, nucleolus .
Tissue expression
Widely and constitutively expressed (PubMed:10562553). Expressed at lower level in colon, peripheral blood lymphocytes, lung and kidney (PubMed:10562553).
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