Molecular weight (DA)
38kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
GNAO Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene represents the alpha subunit of the Go heterotrimeric G-protein signal-transducing complex. Defects in this gene are a cause of early-onset epileptic encephalopathy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015],
Function
function:Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear.,similarity:Belongs to the G-alpha family. G(i/o/t/z) subfamily.,subunit:G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.,
Protein name
Guanine nucleotide-binding protein G(o) subunit alpha
Fields
>>Rap1 signaling pathway;>>Circadian entrainment;>>Retrograde endocannabinoid signaling;>>Glutamatergic synapse;>>Cholinergic synapse;>>Serotonergic synapse;>>GABAergic synapse;>>Dopaminergic synapse;>>Long-term depression;>>Estrogen signaling pathway;>>Melanogenesis;>>Oxytocin signaling pathway;>>Relaxin signaling pathway;>>Morphine addiction;>>Alcoholism;>>Chagas disease;>>Toxoplasmosis;>>Human cytomegalovirus infection;>>Human immunodeficiency virus 1 infection
Human protein sequence Database
P09471
Mouse protein sequence database
P18872
Rat protein sequence database
P59215
Cellular localization
Cell membrane . Membrane ; Lipid-anchor .
Tissue expression
Brain,Endometrium,Myometrium,
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