Molecular weight (DA)
38kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
RN167 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
ring finger protein 167(RNF167) Homo sapiens RNF167 is an E3 ubiquitin ligase that interacts with TSSC5 (SLC22A18; MIM 602631) and, together with UBCH6 (UBE2E1; MIM 602916), facilitates TSSC5 polyubiquitylation (Yamada and Gorbsky, 2006 [PubMed 16314844]).[supplied by OMIM, Mar 2008],
Function
function:May act as an E3 ubiquitin-protein ligase, or as part of the E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2E1, and then transfers it to substrates, such as SLC22A18. May play a role in growth regulation involved in G1/S transition.,pathway:Protein modification; protein ubiquitination.,PTM:Auto-ubiquitinated in vitro in the presence of UBE2D1 and UBE2E1.,similarity:Contains 1 PA (protease associated) domain.,similarity:Contains 1 RING-type zinc finger.,subcellular location:Targeted to cytoplasmic membranes.,subunit:Interacts with SLC22A18.,tissue specificity:Strongly expressed in the kidney and liver (at protein level).,
Protein name
E3 ubiquitin-protein ligase RNF167 (EC 6.3.2.-) (RING finger protein 167) (RING105)
Human protein sequence Database
Q9H6Y7
Mouse protein sequence database
Q91XF4
Rat protein sequence database
Q5XIL0
Cellular localization
Endomembrane system ; Single-pass membrane protein . Targeted to cytoplasmic membranes.
Tissue expression
Strongly expressed in the kidney and liver (at protein level).
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