Molecular weight (DA)
41kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 280-360
Specificity
ADHX Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The encoded protein forms a homodimer. It has virtually no activity for ethanol oxidation, but exhibits high activity for oxidation of long-chain primary alcohols and for oxidation of S-hydroxymethyl-glutathione, a spontaneous adduct between formaldehyde and glutathione. This enzyme is an important component of cellular metabolism for the elimination of formaldehyde, a potent irritant and sensitizing agent that causes lacrymation, rhinitis, pharyngitis, and contact dermatitis. The human genome contains several non-transcribed pseudogenes related to this gene. [provided by RefSeq, Oct 2008],
Function
catalytic activity:An alcohol + NAD(+) = an aldehyde or ketone + NADH.,catalytic activity:S-(hydroxymethyl)glutathione + NAD(P)(+) = S-formylglutathione + NAD(P)H.,cofactor:Binds 2 zinc ions per subunit.,cofactor:Zinc.,function:Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione.,miscellaneous:There are 7 different ADH's isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6.,similarity:Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.,subunit:Homodimer.,
Protein name
Alcohol dehydrogenase class-3 (EC 1.1.1.1) (Alcohol dehydrogenase 5) (Alcohol dehydrogenase class chi chain) (Alcohol dehydrogenase class-III) (Glutathione-dependent formaldehyde dehydrogenase) (FALDH
Fields
>>Glycolysis / Gluconeogenesis;>>Fatty acid degradation;>>Tyrosine metabolism;>>Pyruvate metabolism;>>Retinol metabolism;>>Metabolism of xenobiotics by cytochrome P450;>>Drug metabolism - cytochrome P450;>>Metabolic pathways;>>Carbon metabolism;>>Alcoholic liver disease
Human protein sequence Database
P11766
Mouse protein sequence database
P28474
Rat protein sequence database
P12711
Cellular localization
Cytoplasm .
Tissue expression
Amygdala,B-cell,Liver,Skin,
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