Molecular weight (DA)
45kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 10-90
Specificity
NKAP Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a protein that is involved in the activation of the ubiquitous transcription factor NF-kappaB. This protein is associated with the the histone deacetylase HDAC3 and with the Notch corepressor complex, and it thereby acts as a transcriptional repressor of Notch target genes. It is also required for alphabeta T cell development. A related pseudogene has been identified on chromosome X, while a related and intronless retrocopy, which has an intact CDS and may be functional, is located on chromosome 6. [provided by RefSeq, May 2010],
Function
function:Regulator of TNF and IL-1 induced NF-kappa-B activation.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the UPF0396 family.,
Protein name
NF-kappa-B-activating protein
Human protein sequence Database
Q8N5F7
Mouse protein sequence database
Q9D0F4
Rat protein sequence database
Q4V7C9
Cellular localization
Nucleus .
Tissue expression
B-cell,Cervix,Epithelium,Hepatocyte,Placenta,Small intestine,Testis,
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