Molecular weight (DA)
51kD
Immunogen
The antiserum was produced against synthesized peptide derived from human MEF2C around the phosphorylation site of Ser396. AA range:362-411
Specificity
Phospho-MEF-2C (S396) Polyclonal Antibody detects endogenous levels of MEF-2C protein only when phosphorylated at S396.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This locus encodes a member of the MADS box transcription enhancer factor 2 (MEF2) family of proteins, which play a role in myogenesis. The encoded protein, MEF2 polypeptide C, has both trans-activating and DNA binding activities. This protein may play a role in maintaining the differentiated state of muscle cells. Mutations and deletions at this locus have been associated with severe mental retardation, stereotypic movements, epilepsy, and cerebral malformation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010],
Function
alternative products:Additional isoforms seem to exist,developmental stage:Expression is highest during the early stages of postnatal development, at later stages levels greatly decrease.,domain:The beta domain, missing in a number of isoforms, is required for enhancement of transcriptional activity.,function:Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2.,PTM:Acetylated by p300 on several sites in diffentiating myocytes. Acetylation on Lys-4 increases DNA binding and transactivation.,PTM:Phosphorylation on Se
Protein name
Myocyte-specific enhancer factor 2C
Other name
MEF2C; Myocyte-specific enhancer factor 2C
Fields
>>MAPK signaling pathway;>>cGMP-PKG signaling pathway;>>Apelin signaling pathway;>>Oxytocin signaling pathway;>>Parathyroid hormone synthesis, secretion and action;>>Transcriptional misregulation in cancer;>>Fluid shear stress and atherosclerosis
Human protein sequence Database
Q06413
Mouse protein sequence database
Q8CFN5
Rat protein sequence database
Cellular localization
Nucleus . Cytoplasm, sarcoplasm .
Tissue expression
Expressed in brain and skeletal muscle.
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