Molecular weight (DA)
26kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 60-140
Specificity
U2AF1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene belongs to the splicing factor SR family of genes. U2 auxiliary factor, comprising a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the small subunit which plays a critical role in both constitutive and enhancer-dependent RNA splicing by directly mediating interactions between the large subunit and proteins bound to the enhancers. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008],
Function
domain:The C-terminal SR-rich domain is required for interactions with SR proteins and the splicing regulators TRA and TRA2, and the N-terminal domain is required for formation of the U2AF1/U2AF2 heterodimer.,function:Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the splicing factor SR family.,similarity:Contains 1 RRM (RNA recognition motif) domain.,similarity:Contains 2 C3H1-type zinc fingers.,subunit:Identified in the spliceosome C
Gene Name
U2AF1 U2AF35 U2AFBP FP793
Protein name
Splicing factor U2AF 35 kDa subunit (U2 auxiliary factor 35 kDa subunit) (U2 small nuclear RNA auxiliary factor 1) (U2 snRNP auxiliary factor small subunit)
Fields
>>Spliceosome;>>Shigellosis
Human protein sequence Database
Q01081
Mouse protein sequence database
Q9D883
Rat protein sequence database
Cellular localization
Nucleus . Nucleus speckle .
Tissue expression
B-cell lymphoma,Bone marrow,Epithelium,Fetal brain,Lung,Prostate,Sp
Contract Us
Follow Us
Location： 
Specification
成功添加到购物车