Molecular weight (DA)
88kD
Immunogen
The antiserum was produced against synthesized peptide derived from human SEMA3F. AA range:734-783
Specificity
SEMA3F Polyclonal Antibody detects endogenous levels of SEMA3F protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the semaphorin III family of secreted signaling proteins that are involved in axon guidance during neuronal development. The encoded protein contains an N-terminal Sema domain, an immunoglobulin loop and a C-terminal basic domain. This gene is expressed by the endothelial cells where it was found to act in an autocrine fashion to induce apoptosis, inhibit cell proliferation and survival, and function as an anti-tumorigenic agent. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016],
Function
developmental stage:Detected as early as embryonic day 10.,function:May play a role in cell motility and cell adhesion.,similarity:Belongs to the semaphorin family.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,similarity:Contains 1 Sema domain.,tissue specificity:Expressed abundantly but differentially in a variety of neural and nonneural tissues. There is high expression in mammary gland, kidney, fetal brain, and lung and lower expression in heart and liver.,
Protein name
Semaphorin-3F
Other name
SEMA3F; Semaphorin-3F; Sema III/F; Semaphorin IV; Sema IV
Human protein sequence Database
Q13275
Mouse protein sequence database
O88632
Rat protein sequence database
Cellular localization
Secreted .
Tissue expression
Expressed abundantly but differentially in a variety of neural and nonneural tissues. There is high expression in mammary gland, kidney, fetal brain, and lung and lower expression in heart and liver.
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