Molecular weight (DA)
298kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
CHD6 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
IHC-p 1:50-300. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the SNF2/RAD54 helicase protein family. The encoded protein contains two chromodomains, a helicase domain, and an ATPase domain. Several multi-subunit protein complexes remodel chromatin to allow patterns of cell type-specific gene expression, and the encoded protein is thought to be a core member of one or more of these chromatin remodeling complexes. The encoded protein may function as a transcriptional repressor and is involved in the cellular repression of influenza virus replication. [provided by RefSeq, Jul 2013],
Function
function:Probable transcription regulator.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:The sequence differs from position 1528 onward for unknown reasons.,similarity:Belongs to the SNF2/RAD54 helicase family.,similarity:Contains 1 helicase ATP-binding domain.,similarity:Contains 1 helicase C-terminal domain.,similarity:Contains 2 chromo domains.,tissue specificity:Ubiquitous.,
Gene Name
CHD6 CHD5 KIAA1335 RIGB
Protein name
Chromodomain-helicase-DNA-binding protein 6 (CHD-6) (EC 3.6.4.12) (ATP-dependent helicase CHD6) (Radiation-induced gene B protein)
Human protein sequence Database
Q8TD26
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Nucleus, nucleoplasm . Enriched at sites of mRNA synthesis (PubMed:17027977). During influenza A virus infection, localizes to inactive chromatin. .
Tissue expression
Widely expressed.
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