Molecular weight (DA)
23kD
Immunogen
The antiserum was produced against synthesized peptide derived from human PEBP1. AA range:105-154
Specificity
RKIP Polyclonal Antibody detects endogenous levels of RKIP protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. ELISA: 1/5000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the phosphatidylethanolamine-binding family of proteins and has been shown to modulate multiple signaling pathways, including the MAP kinase (MAPK), NF-kappa B, and glycogen synthase kinase-3 (GSK-3) signaling pathways. The encoded protein can be further processed to form a smaller cleavage product, hippocampal cholinergic neurostimulating peptide (HCNP), which may be involved in neural development. This gene has been implicated in numerous human cancers and may act as a metastasis suppressor gene. Multiple pseudogenes of this gene have been identified in the genome. [provided by RefSeq, Jul 2015],
Function
disease:Stomatin is deficient in overhydrated hereditary stomatocytosis (OHS); also known as cryohydrocytosis or hereditary stomatocytosis. OHS results in red cell anomaly associated with hemolytic anemia. There is increased Na(+)/K(+)-permeability and hence a disorder of cell volume control. The nature of the molecular defect underlying OHS is unknown.,function:Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase.,function:HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor.,function:Thought to regu
Protein name
Phosphatidylethanolamine-binding protein 1
Other name
PEBP1; PBP; PEBP; Phosphatidylethanolamine-binding protein 1; PEBP-1; HCNPpp; Neuropolypeptide h3; Prostatic-binding protein; Raf kinase inhibitor protein; RKIP
Human protein sequence Database
P30086
Mouse protein sequence database
P70296
Rat protein sequence database
Cellular localization
Cytoplasm .
Tissue expression
Bone marrow,Brain,Cajal-Retzius cell,Epithelium,Erythrocyte
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