RBQ-3 Polyclonal Antibody

Polyclonal antibody

Specification

BYab-04112

50UL $180 100UL $255
Delivery： In Stock

Product introduction Experimental scheme Citation Related products

Product introduction>

Host

Reactiveness

Use

Molecular weight (DA)

59kD

Immunogen

Synthesized peptide derived from RBQ-3 . at AA range: 190-270

Specificity

RBQ-3 Polyclonal Antibody detects endogenous levels of RBQ-3 protein.

Source

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Dilution rate

WB 1:500-2000;IHC-p 1:50-300

Purification process (Immunogen)

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Background

This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. The encoded protein binds directly to retinoblastoma protein, which regulates cell proliferation. It interacts preferentially with the underphosphorylated retinoblastoma protein via the E1A-binding pocket B. Three alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2010],

Function

function:Binds preferentially to underphosphorylated retinoblastoma protein.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 6 WD repeats.,subunit:Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2/ASH2L and CXXC1/CFP1. Component of MLL-containing complexes (named MLL, ASCOM, MLL2/MLL3 or MLL3/MLL4 complex): at least composed ASH2L, RBBP5, DPY30, WDR5, one or several histone methyltransferases (MLL, MLL2, MLL3 and/or MLL4), and the facultative components MEN1, HCFC1, HCFC2, NCOA6, KDM6A, PAXIP1/PTIP and C16orf53/PA1.,tissue specificity:Ubiquitously expressed.,

Gene Name

RBBP5

Protein name

Retinoblastoma-binding protein 5

Abbreviation

RBQ-3

Other name

RBBP5; RBQ3; Retinoblastoma-binding protein 5; RBBP-5; Retinoblastoma-binding protein RBQ-3

Fields

>>Cushing syndrome

Human gene ID

5929

Human protein sequence Database

Q15291

Mouse gene ID

213464

Mouse protein sequence database

Q8BX09

Rat gene ID

Rat protein sequence database

Cellular localization

Nucleus .

Tissue expression

Ubiquitously expressed.

Storage

-20°C/1 year

Experimental scheme>

Procedure

RBQ-3 Polyclonal Antibody

BYab-04112

Product introduction>

Host

Reactiveness

Use

Molecular weight (DA)

Immunogen

Specificity

Source

Formulation

Dilution rate

Purification process (Immunogen)

Concentration

Background

Function

Gene Name

Protein name

Abbreviation

Other name

Fields

Human gene ID

Human protein sequence Database

Mouse gene ID

Mouse protein sequence database

Rat gene ID

Rat protein sequence database

Cellular localization

Tissue expression

Storage

Experimental scheme>

Citation(0)>

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RBQ-3 Polyclonal Antibody

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