Molecular weight (DA)
14kD
Immunogen
The antiserum was produced against synthesized peptide derived from human PFDN1. AA range:1-50
Specificity
Prefoldin 1 Polyclonal Antibody detects endogenous levels of Prefoldin 1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. [provided by RefSeq, Jul 2008],
Function
function:Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.,similarity:Belongs to the prefoldin subunit beta family.,subunit:Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.,
Protein name
Prefoldin subunit 1
Other name
PFDN1; PFD1; Prefoldin subunit 1
Human protein sequence Database
O60925
Mouse protein sequence database
Q9CWM4
Rat protein sequence database
Cellular localization
prefoldin complex,
Tissue expression
Colon,Thymus,
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