Molecular weight (DA)
100kD
Immunogen
The antiserum was produced against synthesized peptide derived from human TTK. AA range:642-691
Specificity
TTK Polyclonal Antibody detects endogenous levels of TTK protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
TTK protein kinase(TTK) Homo sapiens This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009],
Function
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.,similarity:Contains 1 protein kinase domain.,tissue specificity:Present in rapidly proliferating cell lines.,
Protein name
Dual specificity protein kinase TTK
Other name
TTK; MPS1; MPS1L1; Dual specificity protein kinase TTK; Phosphotyrosine picked threonine-protein kinase; PYT
Human protein sequence Database
P33981
Mouse protein sequence database
P35761
Rat protein sequence database
Cellular localization
kinetochore,cytoplasm,spindle,membrane,
Tissue expression
Present in rapidly proliferating cell lines.
Contract Us
Follow Us
Location： 
Specification
成功添加到购物车