Molecular weight (DA)
140kD
Immunogen
The antiserum was produced against synthesized peptide derived from human PPP1R3A. AA range:647-696
Specificity
PPP1R3A Polyclonal Antibody detects endogenous levels of PPP1R3A protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The glycogen-associated form of protein phosphatase-1 (PP1) derived from skeletal muscle is a heterodimer composed of a 37-kD catalytic subunit and a 124-kD targeting and regulatory subunit. This gene encodes the regulatory subunit which binds to muscle glycogen with high affinity, thereby enhancing dephosphorylation of glycogen-bound substrates for PP1 such as glycogen synthase and glycogen phosphorylase kinase. [provided by RefSeq, Jul 2008],
Function
disease:Defects in PPP1R3A are a cause of insulin resistance (Ins resistance).,disease:Defects in PPP1R3A are a cause of susceptibility to noninsulin-dependent diabetes mellitus (NIDDM) [MIM:125853]; also known as diabetes mellitus type II. NIDDM is characterized by an autosomal dominant mode of inheritance, onset during adulthood and insulin resistance.,domain:The CBM21 domain is known to be involved in the localization to glycogen and is characteristic of some regulatory subunit of phosphatase complexes.,function:Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Plays an important role in glycogen synthesis but is not essential for insulin activation of glycogen synthase.,PTM:Phosphorylation at Ser-46 by ISPK stimulates the dephosphorylation of
Protein name
Protein phosphatase 1 regulatory subunit 3A
Other name
PPP1R3A; PP1G; Protein phosphatase 1 regulatory subunit 3A; Protein phosphatase 1 glycogen-associated regulatory subunit; Protein phosphatase type-1 glycogen targeting subunit; RG1
Fields
>>Insulin signaling pathway;>>Insulin resistance
Human protein sequence Database
Q16821
Mouse protein sequence database
Q99MR9
Rat protein sequence database
Cellular localization
Membrane ; Single-pass membrane protein .
Tissue expression
Skeletal muscle and heart.
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