Molecular weight (DA)
86kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 400-480
Specificity
ADA30 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
ADAM metallopeptidase domain 30(ADAM30) Homo sapiens This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene is testis-specific and contains a polymorphic region, resulting in isoforms with varying numbers of C-terminal repeats. [provided by RefSeq, Jul 2008],
Function
cofactor:Binds 1 zinc ion per subunit.,domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,function:May be involved in spermatogenesis and fertilization.,similarity:Contains 1 disintegrin domain.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 peptidase M12B domain.,tissue specificity:Expressed specifically in testis.,
Gene Name
ADAM30 UNQ2509/PRO5997
Protein name
Disintegrin and metalloproteinase domain-containing protein 30 (ADAM 30) (EC 3.4.24.-)
Human protein sequence Database
Q9UKF2
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Late endosome membrane ; Single-pass type I membrane protein .
Tissue expression
Expressed in brain neurons (at protein level) (PubMed:27333034). Expressed in testis (PubMed:10512762).
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