Immunogen
The antiserum was produced against synthesized peptide derived from human IPKB. AA range:29-78
Specificity
PKI β Polyclonal Antibody detects endogenous levels of PKI β protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000,WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
protein kinase (cAMP-dependent, catalytic) inhibitor beta(PKIB) Homo sapiens This gene encodes a member of the cAMP-dependent protein kinase inhibitor family. The encoded protein may play a role in the protein kinase A (PKA) pathway by interacting with the catalytic subunit of PKA, and overexpression of this gene may play a role in prostate cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012],
Function
function:Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.,similarity:Belongs to the PKI family.,
Protein name
cAMP-dependent protein kinase inhibitor beta
Other name
PKIB; PRKACN2; cAMP-dependent protein kinase inhibitor beta; PKI-beta
Human protein sequence Database
Q9C010
Mouse protein sequence database
Q04758
Rat protein sequence database
P27775
Cellular localization
nucleus,cytoplasm,
Tissue expression
Placenta,
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