Molecular weight (DA)
34kD
Immunogen
The antiserum was produced against synthesized peptide derived from human NDRG4. AA range:187-236
Specificity
NDRG4 Polyclonal Antibody detects endogenous levels of NDRG4 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that is required for cell cycle progression and survival in primary astrocytes and may be involved in the regulation of mitogenic signalling in vascular smooth muscles cells. Alternative splicing results in multiple transcripts encoding different isoforms.[provided by RefSeq, Jun 2011],
Function
function:May play a role in the early postnatal development and function of neuronal cells.,similarity:Belongs to the NDRG family.,tissue specificity:Expressed only in brain and heart. Isoform 1 and isoform 2 are only expressed in brain. Isoform 3 is expressed in both heart and brain.,
Protein name
Protein NDRG4
Other name
NDRG4; BDM1; KIAA1180; Protein NDRG4; Brain development-related molecule 1; N-myc downstream-regulated gene 4 protein; Vascular smooth muscle cell-associated protein 8; SMAP-8
Human protein sequence Database
Q9ULP0
Mouse protein sequence database
Q8BTG7
Rat protein sequence database
Q9Z2L9
Cellular localization
Cytoplasm, cytosol .
Tissue expression
Expressed predominantly in brain and heart (at protein level). In the brain, detected in astrocytes. Isoform 1 and isoform 2 are only expressed in brain. Isoform 3 is expressed in both heart and brain. Up-regulated in glioblastoma multiforme cells.
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