Molecular weight (DA)
33kD
Immunogen
The antiserum was produced against synthesized peptide derived from human GRAK. AA range:61-110
Specificity
Granzyme K Polyclonal Antibody detects endogenous levels of Granzyme K protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene product is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here lacks consensus sequences for N-glycosylation present in other granzymes. [provided by RefSeq, Jul 2008],
Function
similarity:Belongs to the peptidase S1 family. Granzyme subfamily.,similarity:Contains 1 peptidase S1 domain.,tissue specificity:Expressed in lung, spleen, thymus and peripheral blood leukocytes.,
Other name
GZMK; TRYP2; Granzyme K; Fragmentin-3; Granzyme-3; NK-tryptase-2; NK-Tryp-2
Human protein sequence Database
P49863
Mouse protein sequence database
O35205
Rat protein sequence database
P49864
Cellular localization
Secreted. Cytoplasmic granule.
Tissue expression
Expressed in lung, spleen, thymus and peripheral blood leukocytes.
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