Molecular weight (DA)
39kD
Immunogen
The antiserum was produced against synthesized peptide derived from human MRPL39. AA range:289-338
Specificity
MRP-L39 Polyclonal Antibody detects endogenous levels of MRP-L39 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Two transcript variants encoding distinct isoforms have been described. A pseudogene corresponding to this gene is found on chromosome 5q. [provided by RefSeq, Jul 2008],
Function
caution:It is uncertain whether Met-1 or Met-6 is the initiator.,caution:Ref.1 indicates C21orf8 as a synonym for this orf, this is incorrect, C21orf8 is already assigned to another chromosome 21 region.,similarity:To the N-terminal of threonyl-tRNA synthetases.,tissue specificity:Ubiquitous (isoform 1); heart-specific (isoform 2).,
Protein name
39S ribosomal protein L39 mitochondrial
Other name
MRPL39; C21orf92; MRPL5; RPML5; MSTP003; PRED22; 39S ribosomal protein L39; mitochondrial; L39mt; MRP-L39; 39S ribosomal protein L5, mitochondrial; L5mt; MRP-L5
Human protein sequence Database
Q9NYK5
Mouse protein sequence database
Q9JKF7
Rat protein sequence database
Cellular localization
Mitochondrion .
Tissue expression
Isoform 1 is ubiquitously expressed. Isoform 2 is heart-specific.
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