Molecular weight (DA)
117kD
Immunogen
The antiserum was produced against synthesized peptide derived from human CNKR2. AA range:641-690
Specificity
CNK2 Polyclonal Antibody detects endogenous levels of CNK2 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a multidomain protein that functions as a scaffold protein to mediate the mitogen-activated protein kinase pathways downstream from Ras. This gene product is induced by vitamin D and inhibits apoptosis in certain cancer cells. It may also play a role in ternary complex assembly of synaptic proteins at the postsynaptic membrane and coupling of signal transduction to membrane/cytoskeletal remodeling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009],
Function
function:May function as an adapter protein or regulator of Ras signaling pathways.,PTM:Phosphorylated on tyrosine.,similarity:Belongs to the CNKSR family.,similarity:Contains 1 CRIC domain.,similarity:Contains 1 DUF1170 domain.,similarity:Contains 1 PDZ (DHR) domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,subunit:Interacts with RAF1, RAB2L and RAL GTPase proteins.,
Protein name
Connector enhancer of kinase suppressor of ras 2
Other name
CNKSR2; CNK2; KIAA0902; KSR2; Connector enhancer of kinase suppressor of ras 2; Connector enhancer of KSR 2; CNK homolog protein 2; CNK2
Human protein sequence Database
Q8WXI2
Mouse protein sequence database
Q80YA9
Rat protein sequence database
Q9Z1T4
Cellular localization
Cytoplasm. Membrane; Peripheral membrane protein.
Tissue expression
Brain,Fetal brain,
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