Molecular weight (DA)
80kD
Immunogen
The antiserum was produced against synthesized peptide derived from human F13B. AA range:61-110
Specificity
Factor XIII B Polyclonal Antibody detects endogenous levels of Factor XIII B protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes coagulation factor XIII B subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as a plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon activation by the cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. Factor XIII deficiency is classi
Function
disease:Defects in F13B can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.,function:The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombin.,online information:Factor XIII entry,online information:The Singapore human mutation and polymorphism database,similarity:Contains 10 Sushi (CCP/SCR) domains.,subunit:Tetramer of two A chains and two B chains.,
Protein name
Coagulation factor XIII B chain
Abbreviation
Factor XIII B
Other name
F13B; Coagulation factor XIII B chain; Fibrin-stabilizing factor B subunit; Protein-glutamine gamma-glutamyltransferase B chain; Transglutaminase B chain
Fields
>>Complement and coagulation cascades;>>Coronavirus disease - COVID-19
Human protein sequence Database
P05160
Mouse protein sequence database
Q07968
Rat protein sequence database
Cellular localization
Secreted .
Tissue expression
Heart,Liver,Plasma,
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