Molecular weight (DA)
22kD
Immunogen
The antiserum was produced against synthesized peptide derived from human S100A3. AA range:26-75
Specificity
S-100A3 Polyclonal Antibody detects endogenous levels of S-100A3 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
S100 calcium binding protein A3(S100A3) Homo sapiens The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein has the highest content of cysteines of all S100 proteins, has a high affinity for Zinc, and is highly expressed in human hair cuticle. The precise function of this protein is unknown. [provided by RefSeq, Jul 2008],
Function
function:Binds both calcium and zinc. Probably binds 2 zinc ions per molecule. May be involved in calcium-dependent cuticle cell differentiation and hair shaft formation.,similarity:Belongs to the S-100 family.,similarity:Contains 2 EF-hand domains.,subunit:Homodimer.,tissue specificity:Skin specific.,
Protein name
Protein S100-A3
Other name
S100A3; S100E; Protein S100-A3; Protein S-100E; S100 calcium-binding protein A3
Human protein sequence Database
P33764
Mouse protein sequence database
P62818
Rat protein sequence database
P62819
Cellular localization
Cytoplasm .
Tissue expression
Skin specific, specifically expressed at the inner endocuticle of hair fibers.
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