Molecular weight (DA)
22kD
Immunogen
The antiserum was produced against synthesized peptide derived from human PPIF. AA range:86-135
Specificity
Cyclophilin F Polyclonal Antibody detects endogenous levels of Cyclophilin F protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is part of the mitochondrial permeability transition pore in the inner mitochondrial membrane. Activation of this pore is thought to be involved in the induction of apoptotic and necrotic cell death. [provided by RefSeq, Jul 2008],
Function
catalytic activity:Peptidylproline (omega=180) = peptidylproline (omega=0).,function:PPIases accelerate the folding of proteins.,function:PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.,similarity:Belongs to the cyclophilin-type PPIase family.,similarity:Contains 1 PPIase cyclophilin-type domain.,
Protein name
Peptidyl-prolyl cis-trans isomerase F mitochondrial
Abbreviation
Cyclophilin F
Other name
PPIF; CYP3; Peptidyl-prolyl cis-trans isomerase F; mitochondrial; PPIase F; Cyclophilin F; Rotamase F
Fields
>>Calcium signaling pathway;>>cGMP-PKG signaling pathway;>>Neutrophil extracellular trap formation;>>Alzheimer disease;>>Parkinson disease;>>Huntington disease;>>Spinocerebellar ataxia;>>Prion disease;>>Pathways of neurodegeneration - multiple diseases;>>Toxoplasmosis;>>Chemical carcinogenesis - reactive oxygen species;>>Diabetic cardiomyopathy
Human protein sequence Database
P30405
Mouse protein sequence database
Q99KR7
Rat protein sequence database
P29117
Cellular localization
Mitochondrion matrix .
Tissue expression
Blood,Cord blood,Ovary,
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