Molecular weight (DA)
51kD
Immunogen
The antiserum was produced against synthesized peptide derived from human CPM. AA range:71-120
Specificity
CPM Polyclonal Antibody detects endogenous levels of CPM protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
carboxypeptidase M(CPM) Homo sapiens The protein encoded by this gene is a membrane-bound arginine/lysine carboxypeptidase. Its expression is associated with monocyte to macrophage differentiation. This encoded protein contains hydrophobic regions at the amino and carboxy termini and has 6 potential asparagine-linked glycosylation sites. The active site residues of carboxypeptidases A and B are conserved in this protein. Three alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008],
Function
catalytic activity:Cleavage of C-terminal arginine or lysine residues from polypeptides.,cofactor:Binds 1 zinc ion per subunit.,enzyme regulation:Inhibited by O-phenanthroline and MGTA and activated by cobalt.,function:Specifically removes C-terminal basic residues (Arg or Lys) from peptides and proteins. It is believed to play important roles in the control of peptide hormone and growth factor activity at the cell surface, and in the membrane-localized degradation of extracellular proteins.,similarity:Belongs to the peptidase M14 family.,
Protein name
Carboxypeptidase M
Other name
CPM; Carboxypeptidase M; CPM
Human protein sequence Database
P14384
Mouse protein sequence database
Q80V42
Rat protein sequence database
Cellular localization
Cell membrane ; Lipid-anchor, GPI-anchor .
Tissue expression
Liver,Lung,Placenta,
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