Molecular weight (DA)
41kD
Immunogen
The antiserum was produced against synthesized peptide derived from human CEP41. AA range:150-200
Specificity
CEP41 Polyclonal Antibody detects endogenous levels of CEP41 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a centrosomal and microtubule-binding protein which is predicted to have two coiled-coil domains and a rhodanese domain. In human retinal pigment epithelial cells the protein localized to centrioles and cilia. Mutations in this gene have been associated with Joubert Syndrome 15; an autosomal recessive ciliopathy and neurological disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012],
Function
similarity:Contains 1 rhodanese domain.,tissue specificity:Isoform 1 and isoform 4 are expressed in testis and fetal tissues.,
Protein name
Centrosomal protein of 41 kDa
Other name
CEP41; TSGA14; Centrosomal protein of 41 kDa; Cep41; Testis-specific gene A14 protein
Human protein sequence Database
Q9BYV8
Mouse protein sequence database
Q99NF3
Rat protein sequence database
Cellular localization
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Localizes mainly to the cilium basal body and in primary cilia.
Tissue expression
[Isoform 1]: Expressed in testis and fetal tissues. ; [Isoform 3]: Expressed in testis and fetal tissues.
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