Molecular weight (DA)
36kD
Immunogen
The antiserum was produced against synthesized peptide derived from human BORG4. AA range:201-250
Specificity
Cdc42EP4 Polyclonal Antibody detects endogenous levels of Cdc42EP4 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The product of this gene is a member of the CDC42-binding protein family. Members of this family interact with Rho family GTPases and regulate the organization of the actin cytoskeleton. This protein has been shown to bind both CDC42 and TC10 GTPases in a GTP-dependent manner. When overexpressed in fibroblasts, this protein was able to induce pseudopodia formation, which suggested a role in inducing actin filament assembly and cell shape control. [provided by RefSeq, Jul 2008],
Function
function:Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation, when overexpressed in fibroblasts.,similarity:Belongs to the BORG/CEP family.,similarity:Contains 1 CRIB domain.,subunit:Interacts with CDC42 and RHOQ, in a GTP-dependent manner.,tissue specificity:Not detected in any of the adult tissues tested. May be expressed only in fetal or embryonic tissues.,
Protein name
Cdc42 effector protein 4
Other name
CDC42EP4; BORG4; CEP4; Cdc42 effector protein 4; Binder of Rho GTPases 4
Human protein sequence Database
Q9H3Q1
Mouse protein sequence database
Q9JM96
Rat protein sequence database
Cellular localization
Endomembrane system; Peripheral membrane protein. Cytoplasm, cytoskeleton.
Tissue expression
Not detected in any of the adult tissues tested. May be expressed only in fetal or embryonic tissues.
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