Molecular weight (DA)
28kD
Immunogen
The antiserum was produced against synthesized peptide derived from human BORG1. AA range:10-59
Specificity
Cdc42EP2 Polyclonal Antibody detects endogenous levels of Cdc42EP2 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
CDC42, a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to, and negatively regulate the function of CDC42. Coexpression of this protein with CDC42 suggested a role of this protein in actin filament assembly and cell shape control. [provided by RefSeq, Aug 2011],
Function
domain:The CRIB domain mediates interaction with CDC42.,function:Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner.,similarity:Belongs to the BORG/CEP family.,similarity:Contains 1 CRIB domain.,subunit:Interacts with RHOQ and CDC42 in a GTP-dependent manner, and with SEPT7.,tissue specificity:Highly expressed in the heart. Weakly expressed in the pancreas and liver.,
Protein name
Cdc42 effector protein 2
Other name
CDC42EP2; BORG1; CEP2; Cdc42 effector protein 2; Binder of Rho GTPases 1
Human protein sequence Database
O14613
Mouse protein sequence database
Q8JZX9
Rat protein sequence database
Q5PQP4
Cellular localization
Endomembrane system ; Peripheral membrane protein . Cytoplasm, cytoskeleton .
Tissue expression
Highly expressed in the heart. Weakly expressed in the pancreas and liver.
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