Molecular weight (DA)
65kD
Immunogen
Synthesized peptide derived from Arylsulfatase E . at AA range: 120-200
Specificity
Arylsulfatase E Polyclonal Antibody detects endogenous levels of Arylsulfatase E protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Arylsulfatase E is a member of the sulfatase family. It is glycosylated postranslationally and localized to the golgi apparatus. Sulfatases are essential for the correct composition of bone and cartilage matrix. X-linked chondrodysplasia punctata, a disease characterized by abnormalities in cartilage and bone development, has been linked to mutations in this gene. Alternative splicing results in multiple transcript variants. A pseudogene related to this gene is located on the Y chromosome. [provided by RefSeq, Sep 2013],
Function
cofactor:Binds 1 calcium ion per subunit.,disease:Defects in ARSE are the cause of chondrodysplasia punctata X-linked recessive type 1 (CDPX1) [MIM:302950]. CDP is a clinically and genetically heterogeneous disorder characterized by punctiform calcification of the bones. CDPX1 is a congenital defect of bone and cartilage development characterized by aberrant bone mineralization, severe underdevelopment of nasal cartilage, and distal phalangeal hypoplasia. This disease can also be induced by inhibition with the drug warfarin.,enzyme regulation:Inhibited by millimolar concentrations of warfarin.,function:May be essential for the correct composition of cartilage and bone matrix during development. Has no activity toward steroid sulfates.,PTM:N-glycosylated.,PTM:The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cyste
Protein name
Arylsulfatase E
Abbreviation
Arylsulfatase E
Other name
ARSE; Arylsulfatase E; ASE
Human protein sequence Database
P51690
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Golgi apparatus, Golgi stack .
Tissue expression
Expressed in the pancreas, liver and kidney.
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