Molecular weight (DA)
48kD
Immunogen
The antiserum was produced against synthesized peptide derived from human SYT13. AA range:321-370
Specificity
Synaptotagmin XIII Polyclonal Antibody detects endogenous levels of Synaptotagmin XIII protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
synaptotagmin 13(SYT13) Homo sapiens This gene encodes a member of the large synaptotagmin protein family. Family members have an extracellular N-terminal transmembrane domain and a cytoplasmic C terminus with two tandem C2 domains (C2A and C2B). Synaptotogmin family members can form homo- and heteromeric complexes with each other. They also have different biochemical properties and developmental profiles, and patterns of tissue distribution. Synaptotagmins function as membrane traffickers in multicellular organisms. Two alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011],
Function
domain:The first C2 domain/C2A does not mediate Ca(2+)-dependent phospholipid binding.,domain:The second C2 domain/C2B domain binds phospholipids regardless of whether calcium is present.,function:May be involved in transport vesicle docking to the plasma membrane.,similarity:Belongs to the synaptotagmin family.,similarity:Contains 2 C2 domains.,subunit:Interacts with NRXN1.,tissue specificity:Expressed in brain, pancreas and kidney.,
Protein name
Synaptotagmin-13
Abbreviation
Synaptotagmin XIII
Other name
SYT13; KIAA1427; Synaptotagmin-13; Synaptotagmin XIII; SytXIII
Human protein sequence Database
Q7L8C5
Mouse protein sequence database
Q9EQT6
Rat protein sequence database
Q925B5
Cellular localization
Membrane ; Single-pass membrane protein .
Tissue expression
Expressed in brain, pancreas and kidney.
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