Molecular weight (DA)
50kD
Immunogen
The antiserum was produced against synthesized peptide derived from human Gamma-glutamyltransferase 4. AA range:423-472
Specificity
Cleaved-GGT4 HC (T472) Polyclonal Antibody detects endogenous levels of fragment of activated GGT4 HC protein resulting from cleavage adjacent to T472.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene is a member of a gene family that encodes enzymes involved in both the metabolism of glutathione and in the transpeptidation of amino acids. Changes in the activity of gamma-glutamyltransferase may signal preneoplastic or toxic conditions in the liver or kidney. The protein encoded by this gene consists of a heavy and a light chain, and it can interact with CT120, a plasma membrane-associated protein that is possibly involved in lung carcinogenesis. [provided by RefSeq, Jul 2008],
Function
catalytic activity:(5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl amino acid.,function:Cleaves glutathione conjugates.,pathway:Sulfur metabolism; glutathione metabolism.,similarity:Belongs to the gamma-glutamyltransferase family.,subunit:Heterodimer composed of the light and heavy chains. The active site is located in the light chain (By similarity). Isoform 3 interacts with FAM57A.,tissue specificity:Widely expressed, but at low level, except in the airway epithelial cells. Detected in brain, heart, kidney, liver, lung, spleen, testis and trachea.,
Protein name
Gamma-glutamyltransferase 7
Other name
GGT7; GGTL3; GGTL5; Gamma-glutamyltransferase 7; GGT 7; Gamma-glutamyltransferase-like 3; Gamma-glutamyltransferase-like 5; Gamma-glutamyltranspeptidase 7; Glutathione hydrolase 7
Fields
>>Taurine and hypotaurine metabolism;>>Glutathione metabolism;>>Metabolic pathways
Human protein sequence Database
Q9UJ14
Mouse protein sequence database
Q99JP7
Rat protein sequence database
Q99MZ4
Cellular localization
Membrane ; Single-pass type II membrane protein .
Tissue expression
Widely expressed, but at low level, except in the airway epithelial cells. Detected in brain, heart, kidney, liver, lung, spleen, testis and trachea.
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