Immunogen
The antiserum was produced against synthesized peptide derived from human PPRC1. AA range:1609-1658
Specificity
PRC Polyclonal Antibody detects endogenous levels of PRC protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is similar to PPAR-gamma coactivator 1 (PPARGC1/PGC-1), a protein that can activate mitochondrial biogenesis in part through a direct interaction with nuclear respiratory factor 1 (NRF1). This protein has been shown to interact with NRF1. It is thought to be a functional relative of PPAR-gamma coactivator 1 that activates mitochondrial biogenesis through NRF1 in response to proliferative signals. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013],
Function
function:Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis and cell growth. Involved in the transcription coactivation of CREB and NRF1 target genes.,induction:Up-regulated by serum (at protein level).,similarity:Contains 1 RRM (RNA recognition motif) domain.,subcellular location:Colocalizes with NRF1.,subunit:Interacts with CREB1 and NRF1.,tissue specificity:Strongly expressed in heart and skeletal muscle, moderately in lung, placenta, intestine, liver, kidney, spleen, thymus, colon and brain. Also expressed in several oncocytic thyroid tumors.,
Protein name
Peroxisome proliferator-activated receptor gamma coactivator-related protein 1
Other name
PPRC1; KIAA0595; Peroxisome proliferator-activated receptor gamma coactivator-related protein 1; PGC-1-related coactivator; PRC
Human protein sequence Database
Q5VV67
Mouse protein sequence database
Q6NZN1
Rat protein sequence database
Cellular localization
Nucleus . Colocalizes with NRF1. .
Tissue expression
Strongly expressed in heart and skeletal muscle, moderately in lung, placenta, intestine, liver, kidney, spleen, thymus, colon and brain. Also expressed in several oncocytic thyroid tumors.
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