Molecular weight (DA)
60kd,unspecial bands( 65kd,105kd,130kd)in Hela and HCT116 cell.
Immunogen
The antiserum was produced against synthesized peptide derived from human USP30. AA range:31-80
Specificity
USP30 Polyclonal Antibody detects endogenous levels of USP30 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
USP30, a member of the ubiquitin-specific protease family (see USP1, MIM 603478), is a novel mitochondrial deubiquitinating (DUB) enzyme (Nakamura and Hirose, 2008 [PubMed 18287522]).[supplied by OMIM, Dec 2008],
Function
catalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.,function:May participate in the maintenance of mitochondrial morphology.,similarity:Belongs to the peptidase C19 family.,tissue specificity:Expressed in skeletal muscle, pancreas, liver and kidney.,
Protein name
Ubiquitin carboxyl-terminal hydrolase 30
Other name
USP30; Ubiquitin carboxyl-terminal hydrolase 30; Deubiquitinating enzyme 30; Ubiquitin thioesterase 30; Ubiquitin-specific-processing protease 30; Ub-specific protease 30
Fields
>>Mitophagy - animal
Human protein sequence Database
Q70CQ3
Mouse protein sequence database
Q3UN04
Rat protein sequence database
Cellular localization
Mitochondrion outer membrane .
Tissue expression
Expressed in skeletal muscle, pancreas, liver and kidney.
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