Immunogen
The antiserum was produced against synthesized peptide derived from human SOX12. AA range:71-120
Specificity
Sox-12 Polyclonal Antibody detects endogenous levels of Sox-12 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Members of the SOX family of transcription factors are characterized by the presence of a DNA-binding high mobility group (HMG) domain, homologous to the HMG box of sex-determining region Y (SRY). Forming a subgroup of the HMG domain superfamily, SOX proteins have been implicated in cell fate decisions in a diverse range of developmental processes. SOX transcription factors have diverse tissue-specific expression patterns during early development and have been proposed to act as target-specific transcription factors and/or as chromatin structure regulatory elements. The protein encoded by this gene was identified as a SOX family member based on conserved domains, and its expression in various tissues suggests a role in both differentiation and maintenance of several cell types. [provided by RefSeq, Jan 2013],
Function
function:Binds to the sequence 5'-AACAAT-3'.,similarity:Contains 1 HMG box DNA-binding domain.,tissue specificity:Expressed most abundantly in the CNS. Also expressed in fetal brain and kidney and adult heart, pancreas, testis and ovary. Other tissues were only weakly positive.,
Protein name
Transcription factor SOX-12
Other name
SOX12; SOX22; Transcription factor SOX-12; Protein SOX-22
Human protein sequence Database
O15370
Mouse protein sequence database
Q04890
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Expressed most abundantly in the CNS (PubMed:9215677). Expressed in the heart, pancreas, thymus, testis and ovary (PubMed:9215677). Weakly expressed in brain, placenta, lung, liver, skeletal muscle, kidney, spleen, prostate, small intestine, colon, and peripheral blood lymphocytes (PubMed:9215677).
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