Molecular weight (DA)
55kD
Immunogen
The antiserum was produced against synthesized peptide derived from human UGDH. AA range:391-440
Specificity
UDP-GlcDH Polyclonal Antibody detects endogenous levels of UDP-GlcDH protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010],
Function
catalytic activity:UDP-glucose + 2 NAD(+) + H(2)O = UDP-glucuronate + 2 NADH.,function:Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.,pathway:Nucleotide-sugar biosynthesis; UDP-glucuronic acid biosynthesis; UDP-glucuronic acid from UDP-glucose: step 1/1.,similarity:Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.,subunit:Homohexamer.,
Protein name
UDP-glucose 6-dehydrogenase
Other name
UGDH; UDP-glucose 6-dehydrogenase; UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH
Fields
>>Pentose and glucuronate interconversions;>>Ascorbate and aldarate metabolism;>>Amino sugar and nucleotide sugar metabolism;>>Metabolic pathways;>>Biosynthesis of cofactors;>>Biosynthesis of nucleotide sugars
Human protein sequence Database
O60701
Mouse protein sequence database
O70475
Rat protein sequence database
O70199
Cellular localization
nucleus,nucleoplasm,cytosol,extracellular exosome,
Tissue expression
Detected in heart, placenta, liver, pancreas, spleen, thymus, prostate, ovary, small intestine and colon (PubMed:9737970). Widely expressed (PubMed:9737970).
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